SORBS2 regulates integrin-cytoskeleton interactions and extracellular matrix composition in heart failure

Heart failure is associated with high mortality rates and reduced quality of life. Because of the tight connection between Nppa expression and cardiomyocyte stress, we first determined NPPA correlated genes during heart failure. In this study, we identify SORBS2 as conserved NPPA correlated gene and detail its molecular function and association with heart failure. We used RNA-sequencing on murine whole heart tissue to study the effect of cardiomyocyte-specific genetic loss of Sorbs2 in adult mice in a healthy situation and heart failure model. Overall design: RNA-sequencing was performed on whole ventricular heart tissue in a 2x2 experimental set-up (genotype x condition). (1): Hearts were collected 16 weeks after transverse aortic banding or sham surgery. (2) Both conditions included mice with inducible cardiomyocyte specific knock-out of Sorbs2 at moment of surgery or control mice.