Embryologic Origin Influences Smooth Muscle Cell Phenotypic Modulation Signatures in Murine Marfan Syndrome Aortic Aneurysm. Embryologic Origin Influences Smooth Muscle Cell Phenotypic Modulation Signatures in Murine Marfan Syndrome Aortic Aneurysm

Aortic single-cell RNA sequencing data from second heart field lineage traced mice with Fbn1C1041G/+ and control mice. Overall design: Aortic tissue from 16-week-old control and Fbn1C1041G/+ (Marfan syndrome) mice with transgenic second heart field lineage tracing cre-lox model (Nkx2-5-cre) was subjected to tissue digestion and single-cell RNA sequencing. Male and female replicate pools from each genotype were used, samples were processed from lineage positive and negative cell pools, yielding 8 total samples.