Crystal structure of NDM-1 bound to hydrolyzed imipenem representing an EI2 complex

Crystal structure of NDM-1 bound to hydrolyzed imipenem representing an EI2 complex Descriptor: (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-ca rboxylic acid, CHLORIDE ION, Metallo-beta-lactamase NDM-1, ... Authors: Feng, H, Wang, D, Liu, W. Deposit date: 2017-11-02 Release date: 2018-02-21 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis. Nat Commun, 8, 2017

该数据集为NDM-1与水解型亚胺培南结合的晶体结构，对应EI2复合物。结构描述符：(2R,4S)-2-[(1S,2R)-1-羧基-2-羟丙基]-4-[(2-{[(Z)-亚胺甲基]氨基}乙基)硫烷基]-3,4-二氢-2H-吡咯-5-羧酸、氯离子、金属β-内酰胺酶NDM-1（Metallo-beta-lactamase NDM-1）……。作者：Feng H、Wang D、Liu W。沉积日期：2017-11-02；发布日期：2018-02-21；最后修改日期：2023-11-22。实验方法：X射线衍射（分辨率2 Å）。引用文献：NDM-1催化碳青霉烯水解的机制与青霉素或头孢菌素水解的机制截然不同。《自然·通讯（Nature Communications）》，8卷，2017年。