Iron uptake and transport

The transport of iron between cells is mediated by transferrin. However, iron can also enter and leave cells not only by itself, but also in the form of heme and siderophores. When entering the cell via the main path (by transferrin endocytosis), its goal is not the (still elusive) chelated iron pool in the cytosol nor the lysosomes but the mitochondria, where heme is synthesized and iron-sulfur clusters are assembled (Kurz et al,2008, Hower et al 2009, Richardson et al 2010).Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=917937

细胞间铁的转运由转铁蛋白介导。然而，铁不仅能够以自身形式进入和离开细胞，还能以血红素和铁载体形式进行。当通过主要途径（转铁蛋白内吞作用）进入细胞时，其目的地并非细胞质中尚难以捉摸的螯合铁库，亦非溶酶体，而是线粒体，血红素在此合成，铁硫簇在此组装（Kurz 等人，2008；Hower 等人，2009；Richardson 等人，2010）。Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=917937

搜集汇总

背景与挑战

背景概述

该数据集详细描述了牛体内铁摄取和运输的分子通路，重点阐明了转铁蛋白介导的铁运输机制，以及铁以不同形式(如血红素)进出细胞的途径。数据集包含了通路中涉及的代谢物、蛋白质等分子组分的详细信息，并提供了相关研究文献支持。