Synthesis of Indolizines through Oxidative Linkage of C–C and C–N Bonds from 2‑Pyridylacetates

Synthesis
of indolizine-1-carboxylates through the Ortoleva–King
reaction of 2-pyridylacetate followed by the Aldol condensation under
mild reaction conditions has been described. This protocol is compatible
with a broad range of functional groups, and it has been also successfully
extended to unsaturated ketones, bringing about the regioselective
formation of benzoyl-substituted indolizines through Michael addition
followed by C–N bond formation, which are difficult to prepare
by previous methods in a single step.