Using mathematical models to guide elimination of hepatitis B as a public health threat

This thesis uses mathematical models to provide evidence to guide efforts to eliminate hepatitis B as a public health threat. My work first investigates alternate approaches to deliver hepatitis B birth dose vaccine in low-and middle-income countries, and demonstrates the feasibility, acceptability, safety, importance and cost-effectiveness of their use. Secondly, to promote investment towards elimination, I investigate impact of hepatitis B mortality on global productivity. If nothing was to change, globally US$820 billion would be lost between 2022-2050; but if investment enabled elimination targets to be met by 2030, it would yield returns of US$110 billion by 2050.