Human NK cells under normoxic and hypoxic conditions

Hypoxia, which characterizes most tumor tissues, can alter the function of different immune cell types, favoring tumor escape mechanisms. In this study, we show that hypoxia profoundly acts on NK cells by influencing their transcriptome, affecting their immunoregulatory functions, and changing the chemiotactic responses of different NK cell subsets. The transcriptome of fresh isolated human NK cells cultured under normoxia and hypoxia was studied.