The Ski2-family helicase Obelus regulates Crumbs alternative splicing and cell polarity
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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We identified Obelus, a conserved Ski2-family DExD/H-box helicase in a screen for Drosophila mutants with defects in epithelial polarity and junctional organization. To identify the functional targets of Obelus we used RNA sequencing and compared the transcriptional and splicing profiles of staged wild-type embryos with obe1/obe2Â and obe2/Df(3R)Exel6174 (obe2/Df) mutant embryos.
提供机构：
Sloan Kettering Institute
创建时间：
2022-02-20
