spatial transcriptome

CA1-specific brain tissue from the hippocampal formation was isolated at baseline (homecage condition) in wildtype and NEIL1, NEIL2 or NEIL1&2-deficient mice. NEILs are DNA glycosylases potentially involved in transcription regulation. RNA was extracted and sequenced. Wildtype (C57Bl6) and mice deficient in either NEIL1, NEIL2 or NEIL1 and NEIL2 (C57Bl6-background) were used. Tissue was isolated exclusively at baseline, i.e. the animal was taken directly from its homecage without any behavioral intervention