Summary of the relative potencies of selected NRTIs against telomerase catalysis in vitro.
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*Discrimination Factor (DF): fold increase in concentration of ddNTPs and NRTIs above respective endogenous competitor dNTP required for 50% telomerase inhibition in vitro (IC50).[DF = (IC50NRTI/ddNTP)÷([dNTPcompetitor])].
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2015-12-02
