Crystal structure of human protein kinase CK2alpha' (CSNK2A2 gene product) in complex with the ATP-competitive inhibitor 5,6,7-tribromo-1H-triazolo[4,5-b]pyridine

Crystal structure of human protein kinase CK2alpha' (CSNK2A2 gene product) in complex with the ATP-competitive inhibitor 5,6,7-tribromo-1H-triazolo[4,5-b]pyridine Descriptor: 1,2-ETHANEDIOL, 5,6,7-tris(bromanyl)-1~{H}-[1,2,3]triazolo[4,5-b]pyridine, Casein kinase II subunit alpha' Authors: Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P. Deposit date: 2020-08-15 Release date: 2020-12-09 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (1.01 Å) Cite: Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase. Bioorg.Chem., 106, 2021

人源蛋白激酶CK2α'（CSNK2A2基因编码产物）与ATP竞争性抑制剂（ATP-competitive inhibitor）5,6,7-三溴-1H-三唑并[4,5-b]吡啶的共晶复合物结构
描述组分：1,2-乙二醇、5,6,7-三溴-1H-[1,2,3]三唑并[4,5-b]吡啶、酪蛋白激酶II α'亚基
作者：Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P.
沉积日期：2020-08-15
发布日期：2020-12-09
最后修改日期：2024-05-15
实验方法：X射线衍射（分辨率1.01埃）
引用文献：《新型卤代氮唑并[4,5-b]吡啶类CK2激酶抑制剂的合成、生物学特性与结构研究》，《Bioorg.Chem.》，第106卷，2021年