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The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells

ChEBI2013-06-27 更新2026-07-21 收录

干细胞发育

基因调控轴

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-41758 数据链接链接失效反馈

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The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells

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创建时间：

2013-06-27

干细胞发育

乙酰化调控

The histone lysine acetyltransferase KAT6B (MYST4, MORF, QKF) is the target of recurrent chromosomal translocations causing haematological malignancies with poor prognosis. Using Kat6b germline deleti

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Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates

干细胞发育

前列腺素信号通路

During development, hematopoietic stem cells (HSCs) are produced from the hemogenic endothelium, and will expand in a transient hematopoietic niche. Prostaglandin E2 (PGE2) is essential during vertebr

NIAID Data Ecosystem50

Loss of kdrl marks the shift from embryonic to adult HSPCs

干细胞发育

斑马鱼胚胎模型

Loss of kdrl marks the shift from embryonic to adult HSPCs in zebrafish embryos Overall design: CHTs (5dpf) were dissected and dissociated, using FACS sorting HSPCs were isolated and single cell RNA s

NIAID Data Ecosystem40

Maternal gut microbiota programs stem cell functions in the offspring

母体微生物组

干细胞发育

The maternal-microbiome influences child health. However, its impact on offspring’s stem cells, which regulate development, remains poorly understood.

Figshare2024-03-18 更新50

Developmental cues license emergency megakaryopoiesis in hematopoietic stem cells [bulk RNA-seq & ATAC-seq]

干细胞发育

巨核细胞生成

The fetal to adult switch in mouse hematopoietic stem cell (HSC) behavior is characterized by entry into quiescence and alterations in lineage output. Here we identify the ability of HSCs to undergo e

NIAID Data Ecosystem40

The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells

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