Gene frequencies (%) of the HLA-A, -B, and -C alleles detected and association analysis (N = 4,055).#

*: Amino acid motifs from Lund et al., 2004.†: EP. controls, the controls of NPC free and EBV IgA/VCA antibody positive.‡: EN. controls, the controls of NPC free and EBV IgA/VCA antibody negative.§: Allele also showed significant in the comparison of EP. controls VS. EN. controls, p = 7.81E-06, OR = 0.69(0.59–0.81).#A preliminary analysis of HLA association in phase I was previously reported (Tang et al., 2010). Now, HLA associations with phase I and phase II (See Materials and methods) are presented separately in Table S12.