TOM500: A Multi-Organ Annotated Orbital MRI Dataset for Thyroid Eye Disease

This study presents TOM500, a comprehensive multi-organ annotated orbital magnetic resonance imaging (MRI) dataset. It includes clinical data, T2-weighted MRI scans, and corresponding segmentations from 500 patients with thyroid eye disease (TED) during their initial visit. TED is a common autoimmune disorder with distinct orbital MRI features. Segmentations of nine orbital structures, including the optic nerve, orbital fat, lacrimal gland, eyeball, and five extraocular muscles (superior rectus and levator palpebrae superioris complex, inferior rectus, medial rectus, lateral rectus, and superior oblique), were generated by three junior annotators and reviewed by an expert radiologist. The consistency of the segmentations was evaluated using the intraclass correlation coefficient. Clinical data, including sex, age, disease duration, and smoking status, are also provided for disease diagnosis and classification. TOM500, the largest publicly available orbital MRI dataset with expert annotations, is designed to facilitate the development of advanced computational tools for TED diagnosis, classification, and observation.

本研究推出TOM500——一款多器官标注的全维度眼眶磁共振成像（MRI）数据集。该数据集涵盖了500名初诊甲状腺相关眼病（TED）患者的临床数据、T2加权MRI扫描图像及对应的分割标注。甲状腺相关眼病（TED）是一种常见的自身免疫性疾病，具有特征性的眼眶MRI影像学表现。数据集共标注了9种眼眶结构，包括视神经、眼眶脂肪、泪腺、眼球，以及五条眼外肌：上直肌与提上睑肌复合体、下直肌、内直肌、外直肌与上斜肌；上述分割标注由三名初级标注人员完成，并经放射科专家审核。本研究采用组内相关系数评估了分割标注的一致性。数据集同时提供了患者的性别、年龄、病程与吸烟史等临床数据，可用于疾病诊断与分类任务。TOM500是目前公开可用的规模最大的带专家标注的眼眶MRI数据集，旨在助力面向TED诊断、分类与病情监测的先进计算工具研发。