HORDB: a comprehensive database of hormone peptide

Hormone
peptides are secreted by endocrine cells to act on target cells. They serve as
signal molecules and play vital roles in the regulation of metabolism, growth
and differentiation, etc. They present a unique group of drugs that mimics
natural pathways, especially as supplement therapies where deficient on
endogenous levels. The first clinically used hormone peptide, insulin, has been
used in diabetes for about one hundred years. With the tremendous progress in
protein/peptide detection and quantification procedures, the number of hormone
peptides has increased dramatically. We constructed
HORDB(hordb.cpu-bioinfor.org), a comprehensive database of hormone peptides.
The database holds 6025 entries,including 5729 hormone peptides, 40 peptides
drugs and 256 marketed preparations of these drugs. Each item has detailed
notes, containing basic information, sequence, structure, activity, physics,
and literature. We also added IC50, EC50, ED50 and information about whether to
cross the blood-brain barrier into the activity information annotation.
Peptides with a PDB structure display their structure in the database. In
addition, HOROB integrates search and sequence analysis to facilitate user
browsing and data analysis.