MethylDetectR - A Translational Tool for Methylation-Based Health Profiling

This dataset includes reproducible code for the two applications related to the 'MethylDetectR' software. These .R files are included as 'MethylDetectR - Calculate Your Scores.R' and 'MethylDetectR.R'. An example DNAm file and Sexinfo file for upload to 'MethylDetectR - Calculate Your Scores' are included. These are 'DNAm_File_Example.rds' and 'Sexinfo_example.csv', respectively. An example output file from this application/for upload to 'MethylDetectR' is included as 'MethylDetectR - Test For Upload.csv'. Furthermore, a script for the user to generate their own DNAm-based estimated values for human traits is included as 'Script_For_User_To_Generate_Scores.R'. A necessary associated file as 'Predictors_Shiny_By_Groups.csv' is also present for the script to run. Lastly, coefficients for lifestyle traits and HDL cholesterol are attached as 'Lifestyle_Biochemical_LASSO_Coefficients.xlsx'. These coefficients are separate from those included in the original McCartney and Hillary et al (2018) publication in <em>Genome Biology</em>. The reason for this difference is that the attached coefficients are generated from scaled DNAm data.