Exploratory study evaluating the relationships between perinatal adversity, oxidative stress, and infant neurodevelopment across the first year of life data

Early childhood adversity increases risk for negative lifelong impacts on health and wellbeing. Identifying the risk factors and the associated biological adaptations early in life is critical to develop scalable early screening tools and interventions. Currently, there are limited, reliable early childhood adversity measures that can be deployed prospectively, at scale, to assess risk in pediatric settings. The goal of this two-site study was to determine if the gold standard measure of oxidative stress, F2-Isoprostanes, is potentially a reliable measure of a physiological response to adversity of the infant and mother. The study evaluated the independent relationships between F2-Isoprostanes, perinatal adversity and infant neurocognitive development. The study included mother-infant dyads born >36 weeks’ gestation. Maternal demographic information and mental health assessments were utilized to generate a perinatal cumulative risk score.  Infants’ development was assessed at 6 ..., , , # Data from: Exploratory study evaluating the relationships between perinatal adversity, oxidative stress, and infant neurodevelopment across the first year of life

This dataset includes the following variables that were used in the analysis:

* ID (de-identified participant ID)
* Site (de-identified study site)
* Excluded (participants excluded from data analysis)
* marital_status (marital status): (1-single,2-married,3-cohabitating,4-widowed,5-separated,6-divorced, 99-did not respond)
* m_education (mom education): (1-8th grade of less, 2-some high school, 3-high school/GED, 4-associate degree, 5-bachelor's degree, 6-master's degree, 7-MD, JD, PhD or equivalent, 99-I do not wish to disclose)
* family_income (family income): (1-less than 5K,2-5k-11999K, 3-12k-15999K,4-16k-24999,5-25K-34999,6-35K-49999,7-50k-74999,8-75K-99999,9-100K+,10-I don't know, 99-I do not wish to disclose)

These variables are repeated at 2 months, 6 months, 9 months, and in total:

* phq_#m_tot  (patient health..., We received explicit consent from study participants to publish the de-identified data in the public domain. We removed signifying information like location, coded the study participant ID's, and all other identifying information.