Proteins showing a significantly differential response of abundance between wild-type and CPSF6 knockdown cells upon temperature changes.

Information about all 678 peptides showing a significantly differential temperature response in LFQ intensities (i.e., peptide abundance) between wild-type (WT) and CPSF6-depleted (KD) cells. Column A depicts the corresponding gene symbols. Columns B-Y contain the LFQ intensities for each of the 4 technical replicates in control (WT) and CPSF6-depleted cells at all 3 tested temperatures, namely 32°C, 37°C, and 39°C. Columns Z-AC depict the slope and intercept values of the linear regressions in wild-type and CPSF6-depleted cells, using temperature as independent and LFQ intensities as dependent variables. Columns AD and AE depict corresponding P values and Benjamini–Hochberg corrected P values, respectively, obtained from our statistical test against the null hypothesis that the slopes describing the temperature dependency are identical in wild-type and CPSF6-depleted cells; see Materials and methods for details. (XLS)