Association between 10-year (43 to 53 years) weight change categories and all-cause premature mortality (53 to 65 years) in the 1946 British birth cohort.

Abbreviations: CI, confidence intervals; HR, hazard ratio;1 Based on the sample of participants with available data for mortality and weight change (n = 2 750; deaths = 164).2 Follow-up in person-years.3 Mortality rates are percentages per 1,000 person-years.4 Sample of participants with available data for mortality, weight change and all covariates through model 4 (n = 2 568; deaths = 144).Model 1– unadjusted.Model 2– adjusted for weight at age 43 years and sex.Model 3– as in model 2 plus: educational attainment, socio-economic position, exercise level at 43 and at 53 years.Model 4– as in model 3 plus: cardio-vascular disease and risk factors at 43y (angina, stroke, lung function (FEV1), hypertension), health conditions at 53y (cancer and diabetes history, thyroid and liver disorders, recent major surgery or illness) and smoking habits at 43 and 53y.