The Cancer Genome Atlas

The Cancer Genome Atlas (TCGA), a collaboration between the National Cancer Institute (NCI) and National Human Genome Research Institute (NHGRI), aims to generate comprehensive, multi-dimensional maps of the key genomic changes in major types and subtypes of cancer. TCGA has analyzed matched tumor and normal tissues from 11,000 patients, allowing for the comprehensive characterization of 33 cancer types and subtypes, including 10 rare cancers. The dataset contains open Clinical Supplement, Biospecimen Supplement, RNA-Seq Gene Expression Quantification, miRNA-Seq Isoform Expression Quantification, miRNA Expression Quantification, Genotyping Array Copy Number Segment, Genotyping Array Masked Copy Number Segment, Genotyping Array Gene Level Copy Number Scores, and WXS Masked Somatic Mutation data from Genomic Data Commons (GDC). This dataset also contains controlled Whole Exome Sequencing (WXS), RNA-Seq, miRNA-Seq, ATAC-Seq Aligned Reads, WXS Annotated Somatic Mutation, WXS Raw Somatic Mutation, and WXS Aggregated Somatic Mutation data from GDC. TCGA is made available on AWS via the <a href="https://aws.amazon.com/blogs/publicsector/aws-and-national-institutes-of-health-collaborate-to-accelerate-discoveries-with-strides-initiative/">NIH STRIDES Initiative</a>.

肿瘤基因组图谱（TCGA），系美国国家癌症研究所（NCI）与美国国家人类基因组研究所在（NHGRI）间的合作项目，旨在构建涵盖癌症主要类型及亚型关键基因组变化的综合性、多维度图谱。TCGA通过对11,000名患者的肿瘤与正常组织进行匹配分析，实现了33种癌症类型及亚型的全面表征，其中包括10种罕见癌症。该数据集包含开放的临床补充数据、生物样本补充数据、RNA-Seq基因表达量化数据、miRNA-Seq等位基因表达量化数据、miRNA表达量化数据、基因分型阵列拷贝数段数据、基因分型阵列掩码拷贝数段数据、基因分型阵列基因水平拷贝数评分数据，以及来自基因组数据共享（GDC）的WXS掩码体细胞突变数据。此外，该数据集还包含来自GDC的控制全外显子测序（WXS）、RNA-Seq、miRNA-Seq、ATAC-Seq对齐读取、WXS注释体细胞突变、WXS原始体细胞突变和WXS聚合体细胞突变数据。TCGA项目通过美国国立卫生研究院（NIH）的STRIDES计划在亚马逊网络服务（AWS）上提供，详情请参阅<a href="https://aws.amazon.com/blogs/publicsector/aws-and-national-institutes-of-health-collaborate-to-accelerate-discoveries-with-strides-initiative/">NIH STRIDES计划博客</a>。