Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with erythromycin and protein Y (YfiA) at 2.55A resolution

Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with erythromycin and protein Y (YfiA) at 2.55A resolution Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... Authors: Svetlov, M.S, Syroegin, E.A, Aleksandrova, E.V, Atkinson, G.C, Gregory, S.T, Mankin, A.S, Polikanov, Y.S. Deposit date: 2020-06-19 Release date: 2020-12-23 Last modified: 2025-03-19 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance. Nat.Chem.Biol., 17, 2021

分辨率为2.55埃的结合红霉素与Y蛋白（YfiA）的A2058未甲基化嗜热栖热菌70S核糖体的晶体结构。描述符：(4S)-2-甲基-2,4-戊二醇、16S核糖体RNA、23S核糖体RNA等。作者：Svetlov, M.S.、Syroegin, E.A.、Aleksandrova, E.V.、Atkinson, G.C.、Gregory, S.T.、Mankin, A.S.、Polikanov, Y.S.。沉积日期：2020-06-19，发布日期：2020-12-23，最后修改日期：2025-03-19。实验方法：X射线衍射（2.55 Å）。引用：《经Erm修饰的70S核糖体结构揭示大环内酯类耐药机制》，《自然·化学生物学》，17卷，2021年。