Vaccine driven lung TRM cells provide immunity against Klebsiella via fibroblast IL-17R signaling

Subunit vaccine elicits lung tissue resident memmory CD4+ T-cells and confers lung protection against heterologous strain Overall design: I. We harvested the lungs from Il17raDermoCre negative and positive mice at 4 hours post challenge with 10^4 CFU K1 strain (KP396) and extracted the whole RNAs. We chose this time point based on the similar CFU between groups because any differences in gene expression would not be due to lung bacterial burdens.