Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing bi-specific antibody CAP256L-R27 targeting the CD4-binding site and the V2-apex
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Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing bi-specific antibody CAP256L-R27 targeting the CD4-binding site and the V2-apex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 BG505 DS-SOSIP gp120, ... Authors: Zhou, T, Morano, N.C, Roark, R.S, Kwong, P.D, Xu, J. Deposit date: 2023-08-01 Release date: 2024-05-08 Last modified: 2024-12-18 Method: ELECTRON MICROSCOPY (3.61 Å) Cite: Ultrapotent Broadly Neutralizing Human-llama Bispecific Antibodies against HIV-1. Adv Sci, 11, 2024
靶向CD4结合位点与V2顶端区域的广谱中和双特异性抗体CAP256L-R27复合物中HIV-1包膜蛋白（HIV-1 Env）BG505 DS-SOSIP的冷冻电子显微镜（Cryo-EM）结构 组成成分：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、HIV-1 BG505 DS-SOSIP gp120等 作者：Zhou, T、Morano, N.C、Roark, R.S、Kwong, P.D、Xu, J. 提交日期：2023-08-01 发布日期：2024-05-08 最后修订日期：2024-12-18 检测方法：电子显微镜（分辨率3.61 Å） 引用文献：《抗HIV-1的超广谱中和人源-羊驼双特异性抗体》，《Advanced Science》，2024年，第11卷
