Ovarian infertility

Ovarian bottleneck genes associated with infertility. A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility phenotypes. The individual gene pages in the OKdb (Ovarian Kaleidoscope Database: http://ovary.stanford.edu) contain information on associated fertility phenotypes sorted by ovarian and nonovarian defects and by subfertility or infertility. If one searches for null mutations (under mutation type) causing infertility (infertile - ovarian defect, under female fertility status) in mice (under species), 44 gene entries are found. The expression of these infertility genes in the oocyte and granulosa cells together with their cellular localization is presented in Ovarian Infertility gene map. The theca cell genes are not presented because most publications emphasize granulosa cell studies. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP34 CPTAC Assay Portal]

卵巢瓶颈基因与不孕症相关。研究不孕症的有效途径之一，是对与不孕症表型相关的人类和鼠类基因突变进行比较。OKdb（卵巢万花筒数据库：http://ovary.stanford.edu）中的个体基因页面包含了按卵巢和非卵巢缺陷以及亚不孕或不孕进行分类的关联生育表型信息。若在鼠类（物种分类）下搜索导致不孕的null突变（突变类型），在女性生育状态（生育状况）下的卵巢缺陷，共找到44个基因条目。这些不孕基因在卵母细胞和颗粒细胞中的表达及其细胞定位在卵巢不孕基因图谱中呈现。由于大多数出版物强调颗粒细胞研究，因此未呈现卵泡细胞基因。该通路上的蛋白质具有通过[https://assays.cancer.gov/available_assays?wp_id=WP34 CPTAC检测门户]可获得的靶向检测方法。