Processed data for: Co-registration of heading to visual cues in retrosplenial cortex

Spatial cognition depends on an accurate representation of orientation
within an environment. Head direction cells in distributed brain regions
receive a range of sensory inputs, but visual input is particularly
important for aligning their responses to environmental landmarks. To
investigate how population-level heading responses are aligned to visual
input, we recorded from retrosplenial cortex (RSC) of head-fixed mice in a
moving environment using two-photon calcium imaging. We show that RSC
neurons are tuned to the animal's relative orientation in the
environment, even in the absence of head movement. Next, we found that RSC
receives functionally distinct projections from visual and thalamic areas,
and contains several functional classes of neurons. While some functional
classes mirror RSC inputs, a newly discovered class coregisters visual and
thalamic signals. Finally, decoding analyses reveal unique contributions
to heading from each class. Our results suggest an RSC circuit for
anchoring heading representations to environmental visual landmarks.