DNA damage response-related parameters and associated Wilcoxon rank-sum tests in PBMCs from healthy volunteers and OC patients, sensitive or resistant to platinum therapy.

1HV, Healthy volunteers2PS, Platinum-sensitive patients3PR, Platinum-resistant patients4PBMCs that are defined as having more than 5 foci per cell, expressed as a fraction of 1005Olive Tail Moment (OTM) values, arbitrary units6AUC values, expressed as (% of γH2AX positive staining cells) x (carboplatin dose)7AUC values (expressed as OTM x carboplatin dose)8t1/2 for γH2AX foci removal, in h9t1/2 values for carboplatin-induced damage repair, in h10apoptosis rates expressed as doses of carboplatin inducing apoptosis (as defined in the Materials and Methods section)11AUC values, expressed as (% of pan-nuclear staining cells) x (carboplatin dose)12Wilcoxon rank-sum testsDNA damage response-related parameters and associated Wilcoxon rank-sum tests in PBMCs from healthy volunteers and OC patients, sensitive or resistant to platinum therapy.