Crystal structure of HRAS-G12D/Q95H (GMPPNP-bound) in complex with BBO-11818

Crystal structure of HRAS-G12D/Q95H (GMPPNP-bound) in complex with BBO-11818 Descriptor: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... Authors: Chan, A.H, Bratcher, D.R, Simanshu, D.K. Deposit date: 2025-06-16 Release date: 2025-12-03 Last modified: 2026-04-15 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants. Cancer Discov, 16, 2026

与BBO-11818形成复合物的HRAS-G12D/Q95H（结合GMPPNP）晶体结构。描述：GTP酶（GTPase）HRas、镁离子（MAGNESIUM ION）、磷酰氨基膦酸鸟苷酯（PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER）…… 作者：Chan, A.H、Bratcher, D.R、Simanshu, D.K。存档日期：2025-06-16；发布日期：2025-12-03；最后修改日期：2026-04-15。实验方法：X射线衍射（分辨率2.02埃）。引用文献：《BBO-11818的发现：一种强效且选择性靶向（激活态与失活态）KRAS的非共价抑制剂，对多种致癌突变体具有活性》，《癌症发现》，16卷，2026年。