Structure of AAC(6')-Iy in complex with bisubstrate analog CoA-S- monomethyl-acetylneamine.

Structure of AAC(6')-Iy in complex with bisubstrate analog CoA-S- monomethyl-acetylneamine. Descriptor: (3R,9Z)-17-[(2R,3S,4R,5R,6R)-5-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-3,4-dihydroxytetrahydro-2H-pyran-2-yl]-3-hydroxy-2,2-dimethyl-4,8,15-trioxo-12-thia-5,9,16-triazaheptadec-9-en-1-yl [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl dihydrogen diphosphate, AMINOGLYCOSIDE 6'-N-ACETYLTRANSFERASE, GLYCEROL, ... Authors: Vetting, M.W, Magalhaes, M.L, Freiburger, L, Gao, F, Auclair, K, Blanchard, J.S. Deposit date: 2007-09-14 Release date: 2008-01-08 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2 Å) Cite: Kinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella Enterica Aminoglycoside 6'-N-Acetyltransferase. Biochemistry, 47, 2008

AAC(6')-Iy与双底物类似物（bisubstrate analog）CoA-S-单甲基-乙酰新霉胺复合物的结构。描述项：(3R,9Z)-17-[(2R,3S,4R,5R,6R)-5-氨基-6-{[(1R,2R,3S,4R,6S)-4,6-二氨基-2,3-二羟基环己基]氧基}-3,4-二羟基四氢-2H-吡喃-2-基]-3-羟基-2,2-二甲基-4,8,15-三氧代-12-硫杂-5,9,16-三氮杂十七碳-9-烯-1-基 [(2R,3S,4R,5R)-5-(6-氨基-9H-嘌呤-9-基)-4-羟基-3-(膦酰氧基)四氢呋喃-2-基]甲基二氢二磷酸酯；氨基糖苷6'-N-乙酰基转移酶（AMINOGLYCOSIDE 6'-N-ACETYLTRANSFERASE）；甘油（GLYCEROL）等。作者：Vetting M.W.、Magalhaes M.L.、Freiburger L.、Gao F.、Auclair K.、Blanchard J.S.。保藏日期：2007-09-14；发布日期：2008-01-08；最后修改日期：2024-05-08。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2 Å）。引用文献：《肠道沙门氏菌氨基糖苷6'-N-乙酰基转移酶的双底物抑制动力学与结构分析》，《生物化学（Biochemistry）》，第47卷，2008年。