Pathogenic Bacteria Exploit Transferrin Receptor Transcytosis to Penetrate the Blood‒Brain Barrier

In this study, we present evidence showing that the infection with the major meningitis-causing bacteria, NMEC, GBS and SPN, activates the same fusion process of bacteria-containing vesicles (BCVs) with TfR vesicles, which enables those bacteria to exploit TfR transcytosis to penetrate the BBB, and illustrate the details of this process in HBMECs and mouse models.