Additional file 1 of Genetic evidence for a causal relationship between type 2 diabetes and peripheral artery disease in both Europeans and East Asians

Additional file 1: Table S1. ICD codes of PAD and T2D. Table S2. MR results between T2D and PAD in Europeans. Table S3. MR results between T2D and PAD in Europeans (without excluding potential pleiotropy SNPs). Table S4. MVMR results between T2D and PAD adjusted by potential risk factors in Europeans. Table S5. Summary of PRS regression of PRS for T2D on PAD status in Europeans. Table S6. Summary of PRS regression of PRS for PAD on T2D status in Europeans. Table S7. Novel SNPs underlying the shared genetics of T2D and PAD in Europeans detected by MTAG. Table S8. Candidate genes associated with comorbid T2D and PAD in Europeans detected by MAGMA. Table S9. Significant SMR associations of gene expression (from Table S8) with T2D, PAD, and their cross-trait. Table S10. MR results between T2D and PAD in East Asians. Table S11. MR results between T2D and PAD in East Asians (without excluding potential pleiotropy SNPs). Table S12. MVMR results between T2D and PAD adjusted by potential risk factors in East Asians. Table S13. Summary of PRS regression of PRS for T2D on PAD status in East Asians. Table S14. Summary of PRS regression of PRS for PAD on T2D status in East Asians. Table S15. Candidate genes associated with comorbid T2D and PAD in East Asians detected by MAGMA. Table S16. Significant SMR associations of gene expression (from Table S15) with T2D, PAD, and their cross-trait. (XLS 383 kb)附加文件1：表S1：外周动脉疾病（PAD, Peripheral Arterial Disease）与2型糖尿病（T2D, Type 2 Diabetes）的国际疾病分类（ICD, International Classification of Diseases）编码；表S2：欧洲人群中2型糖尿病与外周动脉疾病的孟德尔随机化（MR, Mendelian Randomization）分析结果；表S3：欧洲人群中2型糖尿病与外周动脉疾病的孟德尔随机化分析结果（未排除潜在多效性单核苷酸多态性（SNPs, Single Nucleotide Polymorphisms））；表S4：欧洲人群中经潜在危险因素校正后的2型糖尿病与外周动脉疾病的多变量孟德尔随机化（MVMR, Multivariable Mendelian Randomization）分析结果；表S5：欧洲人群中以2型糖尿病多基因风险评分（PRS, Polygenic Risk Score）为自变量、外周动脉疾病患病状态为因变量的PRS回归分析总结；表S6：欧洲人群中以外周动脉疾病PRS为自变量、2型糖尿病患病状态为因变量的PRS回归分析总结；表S7：欧洲人群中通过多性状分析（MTAG, Multi-Trait Analysis of Genome-wide Association Studies）检测到的2型糖尿病与外周动脉疾病共享遗传基础的新型单核苷酸多态性（SNPs）；表S8：欧洲人群中通过MAGMA工具检测到的与2型糖尿病和外周动脉疾病共病相关的候选基因；表S9：源自表S8的基因表达与2型糖尿病、外周动脉疾病及其跨性状关联的显著孟德尔随机化共定位（SMR, Summary-based Mendelian Randomization）关联；表S10：东亚人群中2型糖尿病与外周动脉疾病的孟德尔随机化分析结果；表S11：东亚人群中2型糖尿病与外周动脉疾病的孟德尔随机化分析结果（未排除潜在多效性单核苷酸多态性）；表S12：东亚人群中经潜在危险因素校正后的2型糖尿病与外周动脉疾病的多变量孟德尔随机化分析结果；表S13：东亚人群中以2型糖尿病PRS为自变量、外周动脉疾病患病状态为因变量的PRS回归分析总结；表S14：东亚人群中以外周动脉疾病PRS为自变量、2型糖尿病患病状态为因变量的PRS回归分析总结；表S15：东亚人群中通过MAGMA工具检测到的与2型糖尿病和外周动脉疾病共病相关的候选基因；表S16：源自表S15的基因表达与2型糖尿病、外周动脉疾病及其跨性状关联的显著孟德尔随机化共定位关联。（XLS格式，文件大小383 KB）