Global network analysis of differentially expressed genes.

Up- and down-regulated genes from L235 analyzed using the IPA tool (version 4.0). Among them 74 up- and 52 down-regulated genes were eligible for generating networks and led to the identification respectively of 10 and 11 distinct networks containing both direct and indirect interactions scored by significance. The six up and four down-regulated networks considered as relevant (i.e. score>3) are reported. Genes selected as differentially expressed in [PIP+] versus [PIP−] samples (i.e. Focus genes) are shown in bold. Underlined genes indicate those belonging to multiple networks. The other genes are either absent from the microarray or found not significantly regulated.