In adult K14ΔNLef1 mouse, the overexpression of ∆NLef1, a B-catenin dominat negative, in basal keratinocytes leads to the conversion of hair follicles into multilayered epithelial cysts and ectopic se

NIAID Data Ecosystem60

Differential usage of Zeb2 enhancer distinguishes adult and embryonic hematopoiesis [bulkATAC-seq]. Differential usage of Zeb2 enhancer distinguishes adult and embryonic hematopoiesis [bulkATAC-seq]

B细胞表观遗传学

增强子功能研究

ATAC-seq of Zeb2 WT and Zeb2 enhancer KO B cells Overall design: Epigenetic differences induced by KO of an enhancer of Zeb2 in mouse B cells

NIAID Data Ecosystem40

Loss of Apc impairs Lgr5+ intestinal stem cell fate programs [RRBS]

结直肠癌分子机制

细胞命运调控

Loss of APC is the main driving alteration associated with colorectal cancer (CRC) development. We investigate the immediate outcome of this genetic event on the transcriptomic and DNA methylation pro

NIAID Data Ecosystem60

Oscillations of the p53-Akt Network: Implications on Cell Survival and Death

细胞命运调控

P53信号通路

Intracellular protein levels of p53 and MDM2 have been shown to oscillate in response to ionizing radiation (IR), but the physiological significance of these oscillations remains unclear. The p53-MDM2

NIAID Data Ecosystem40

Switch Enhancer Elements Control Cell Fate in Human Embryonic Stem Cells

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