Molecular Basis of AmpC Hyperproduction in Clinical Isolates of Escherichia coli

Name: Molecular Basis of AmpC Hyperproduction in Clinical Isolates of Escherichia coli
Creator: American Society for Microbiology (ASM)
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PubMed Central2026-05-16 收录

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https://pmc.ncbi.nlm.nih.gov/articles/PMC89235/

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DNA sequencing data showed that five clinical isolates of Escherichia coli with reduced susceptibility to ceftazidime, ceftriaxone, and cefotaxime contain an ampC gene that is preceded by a strong promoter. Transcription from the strong promoter was 8- to 18-fold higher than that from the promoter from a susceptible isolate. RNA studies showed that mRNA stability does not play a role in the control of AmpC synthesis.

提供机构：

American Society for Microbiology (ASM)