Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a biarylamine based inhibitor

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a biarylamine based inhibitor Descriptor: 2-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}amino)-N-(2,4-difluorophenyl)pyridine-3-carboxamide, Hepatocyte growth factor receptor Authors: Sack, J. Deposit date: 2010-01-04 Release date: 2010-05-05 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010

肝细胞生长因子受体（hepatocyte growth factor receptor）C-MET的酪氨酸激酶结构域（tyrosine kinase domain）与基于二芳基胺的抑制剂形成复合物的晶体结构。抑制剂标识符：2-({4-[(2-氨基吡啶-4-基)氧基]-3-氟苯基}氨基)-N-(2,4-二氟苯基)吡啶-3-甲酰胺；靶标为肝细胞生长因子受体。作者：Sack, J.。提交日期：2010-01-04；发布日期：2010-05-05；最后修改日期：2023-09-06。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.4埃。引用信息：《新型基于二芳基胺的Met激酶抑制剂的设计、合成及构效关系》，发表于《Bioorg.Med.Chem.Lett.》20卷，2010年。