Transcriptomic analysis of senescent cells upon EXOC7 knockdown.
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=183939caf12cbfcc8dd4807f9bcbb763
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资源简介：
IMR90 ER:RAS cells were transfected with scramble siRNA or 2 deconvoluted siRNAs targeting EXOC7 or an siRNA targeting PTBP1. The next day the cells were treated with 4OHT to induce senescence. 5 days later the cells were collected for total mRNA analysis. Our previous experiments had shown that alternative splicing of EXOC7 depends on PTBP1 and PTBP1 is a target for suppressing pro-inflammatory factors in senescence. By performing RNA-seq we confirmed that the pro-inflammatory factors whose expression depends on PTBP1 equally depends on EXOC7.
提供机构：
MRC London Institute of Medical Sciences
创建时间：
2022-02-20
