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Diastereoselective Synthesis of γ-Lactams by a One-Pot, Four-Component Reaction

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https://figshare.com/articles/dataset/Diastereoselective_Synthesis_of_Lactams_by_a_One_Pot_Four_Component_Reaction/2983909
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A new one-pot, four-component reaction (4CR) between amines, maleic anhydrides, aldehydes, and thiols has been discovered to form tetra- and pentasubstituted γ-lactams with high diastereoselectivity. Each component is independently variable and employed in equivalent stoichiometry, producing only water as a byproduct.
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2016-06-03
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