Catalytic domain of LytA, the major autolysin of Streptococcus pneumoniae, (C60A, H133A, C136A mutant) complexed with peptidoglycan fragment

Catalytic domain of LytA, the major autolysin of Streptococcus pneumoniae, (C60A, H133A, C136A mutant) complexed with peptidoglycan fragment Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-methyl 2-acetamido-3-O-[(1R)-1-carboxyethyl]-2-deoxy-beta-D-glucopyranoside-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-methyl 2-acetamido-3-O-[(1R)-1-carboxyethyl]-2-deoxy-beta-D-glucopyranoside, Autolysin, fragment of peptidoglycan Authors: Achour, A, Sandalova, T, Mellroth, P. Deposit date: 2015-07-24 Release date: 2016-06-15 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.05 Å) Cite: The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity. Mol.Microbiol., 101, 2016

肺炎链球菌（Streptococcus pneumoniae）主要自溶素（autolysin）LytA的催化结构域（C60A、H133A、C136A突变体）与肽聚糖（peptidoglycan）片段结合的复合物。配体描述符：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-3-O-[(1R)-1-羧乙基]-2-脱氧-β-D-吡喃葡萄糖酸甲酯-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-3-O-[(1R)-1-羧乙基]-2-脱氧-β-D-吡喃葡萄糖酸甲酯。研究组分：自溶素、肽聚糖片段。作者：Achour A、Sandalova T、Mellroth P。沉积日期：2015-07-24；发布日期：2016-06-15；最后修改日期：2024-11-06。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.05 Å）。引用文献：《与大型肽聚糖片段结合的肺炎链球菌主要自溶素LytA的晶体结构揭示聚糖对裂解活性的关键作用》，Mol.Microbiol.，101卷，2016年