Investigating the Gut Microbiome in Central Disorders of Hypersomnolence. Investigating the Gut Microbiome in Central Disorders of Hypersomnolence

Microbiota affects the central nervous system by modulation of neuronal pathways, through the neuroendocrine and immune system, hypothalamus-pituitary-adrenal axis, and various metabolic pathways. Microbiota can also influence the circadian rhythms of the host. The gut microbiota affects sleep mostly through the production of neurotransmitters and short-chain fatty acids. In this study, we observed the gut microbiota composition of patients suffering from narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia.