T2R-TTL-PROTAC1 complex

T2R-TTL-PROTAC1 complex Descriptor: (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 4-{2-[4-({2-[2-({2-[(3R)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}amino)ethoxy]ethoxy}methyl)-1H-1,2,3-triazol-1-yl]ethyl}benzoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... Authors: Maiocchi, A, Abel, A.-C, Steinmetz, M.O, Passarella, D, Prota, A.E. Deposit date: 2024-10-15 Release date: 2025-10-29 Last modified: 2026-05-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Effective Tubulin Degradation by Rationally Designed Proteolysis Targeting Chimeras Biorxiv, 2025T2R-TTL-PROTAC1复合物描述符：(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-氯-21-羟基-12,20-二甲氧基-2,5,9,16-四甲基-8,23-二氧代-4,24-二氧杂-9,22-二氮杂四环[19.3.1.1~10,14~.0~3,5~]二十六碳-10(26),11,13,16,18-五烯-6-基 4-{2-[4-({2-[2-({2-[(3R)-2,6-二氧代哌啶-3-基]-1,3-二氧代-2,3-二氢-1H-异吲哚-4-基}氨基)乙氧基]乙氧基}甲基)-1H-1,2,3-三唑-1-基]乙基}苯甲酸酯、2-(N-吗啉代)乙磺酸、钙离子…… 作者：Maiocchi A、Abel A.-C、Steinmetz M.O、Passarella D、Prota A.E。存入日期：2024-10-15；发布日期：2025-10-29；最后修改日期：2026-05-13。研究方法：X射线衍射（分辨率2.3埃）。引用文献：《通过理性设计的蛋白降解靶向嵌合体实现高效微管蛋白降解》，BioRxiv，2025年。