Mus musculus musculus Raw sequence reads

Introduction: microRNAs (miRNAs) and their mRNA 3' untranslated region (3'UTR) targets could be expressed as multiple processing variants. Each variant could have different targeting properties, which could thus affect miRNA-mediated regulation in the cell. We aim to comprehensively uncover these processing variants in the heart and evaluate their changes during cardiac hypertrophy.Methods: Transverse Aortic Constriction (TAC) was performed to induce cardiac hypertrophy in C57BL/6 mice. RNAs were extracted from the cardiomyocytes of sham-treated, pre-hypertrophic (2 days post-TAC), and hypertrophic (7 days post-TAC) mice, then subjected to small RNA- and polyA-tail (PAT)- sequencings.