Molecular Heterogeneity of SLE Disease Activity

In this study, a broad multi-omic analysis of differences in SLE disease activity by race was used to determine differences in the cellular and molecular presentation of disease. Data from CyTOF (immunophenotyping & phospho-Cytof), multioplex soluble mediators (both baseline plasma and stimulated secreted), EpiTOF, and scRNA-Seq/51-plex CITE-Seq are systematically collected from the sample subjects at the same visits across a very deeply clinically phenotyped cohort matched for age, race and sex.