Novel Radiolabeled Vanilloid with Enhanced Specificity for Human Transient Receptor Potential Vanilloid 1 (TRPV1)
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https://figshare.com/articles/dataset/Novel_Radiolabeled_Vanilloid_with_Enhanced_Specificity_for_Human_Transient_Receptor_Potential_Vanilloid_1_TRPV1_/5427211
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资源简介：
Transient receptor
potential vanilloid 1 (TRPV1) has emerged as
a promising therapeutic target. While radiolabeled resiniferatoxin
(RTX) has provided a powerful tool for characterization of vanilloid
binding to TRPV1, TRPV1 shows 20-fold weaker binding to the human
TRPV1 than to the rodent TRPV1. We now describe a tritium radiolabeled
synthetic vanilloid antagonist, 1-((2-(4-(methyl-[3H])piperidin-1-yl-4-[3H])-6-(trifluoromethyl)pyridin-3-yl)methyl)-3-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)urea ([3H]MPOU), that embodies improved absolute affinity for human
TRPV1 and improved synthetic accessibility.
创建时间：
2017-09-11
