Data for: A neural circuit for wind-guided olfactory navigation

To navigate towards a food source, animals must frequently combine odor
cues that tell them what sources are useful with wind direction cues that
tell them where the source can be found.  Where and how
these two cues are integrated to support navigation is
unclear.  Here we identify a pathway to
the Drosophila fan-shaped body (FB) that encodes
attractive odor and promotes upwind navigation. We show that neurons
throughout this pathway encode odor, but not wind direction. Using
connectomics, we identify FB local neurons called h∆C that receive input
from this odor pathway and a previously described wind
pathway.  We show that h∆C neurons exhibit odor-gated,
wind direction-tuned activity, that sparse activation of h∆C neurons
promotes navigation in a reproducible direction, and that h∆C activity is
required for persistent upwind orientation during
odor.  Based on connectome data, we develop a
computational model showing how h∆C activity can promote navigation
towards a goal such as an upwind odor source.  Our
results suggest that odor and wind cues are processed by separate pathways
and integrated within the FB to support goal-directed navigation.