Vitamin D supplementation and cardiac function (Vitamina D; PI: M Turiel)

Raw data of the clinical trial NCT03403933. We enrolled 47 older adults scheduled for major orthopaedic surgery and suffering from hypovitaminosis D. Patients underwent 6-months calcifediol supplementation with a starting dose at first post-operative day of 50 µg/die in liquid preparation. Down-titration to 20 µg/die at 3-months assessment was planned. Cardiac performance was evaluated by measuring left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) during pre-operative assessments and at 1-month, 3-months, 6-months follow-ups. The dataset was used to write the article "Correction of hypovitaminosis D improved global longitudinal strain earlier than left ventricular ejection fraction in cardiovascular older adults after orthopaedic surgery", which was published by the Journal of Geriatric Cardiology in 2018.

本数据集收录了临床试验NCT03403933的原始数据。该试验纳入了47名计划接受大型骨科手术且患有维生素D缺乏症的老龄成人。受试者接受了为期6个月的钙化醇补充治疗，初始剂量为首次术后第1天50 µg/die的液体制剂。在3个月评估时，剂量下调至20 µg/die。通过测量术前评估及术后1个月、3个月、6个月的左心室射血分数（LVEF）和全局纵向应变（GLS）来评估心脏功能。该数据集被用于撰写发表在2018年《老年心脏病学杂志》上的文章《纠正维生素D缺乏症可提前改善心血管老龄成人的全局纵向应变，优于左心室射血分数》。