Effect of LRP1 deletion in vascular mural cells and APOE gentotype on gene expression in mouse brains. Effect of LRP1 deletion in vascular mural cells and APOE gentotype on gene expression in mouse brains

To investigate the apoE isoform-dependent role of vascular mural cell (VMC)-LRP1, we generated VMC-specific LRP1 knockout mice (smLrp1-/-), followed by breeding these mice with either APOE3-targeted replacement (TR) or APOE4-TR mice We then performed gene expression profiling analysis using data obtained from RNA-seq of cortical samples from 4 different mouse models Overall design: Comparative gene expression profiling analysis of RNA-seq data for VMC-LRP1 deificency in the presenc eof apoE3 or apoE4