Replication in the JCS subject set.

Lists of the SNPs in ADARB2 and ADARB1 that reach statistical significance in the NECS and SICS and were attempted to be replicated in the JCS set. The first 7 columns report the details of the SNPs as described in the legend of Table 3. Columns 8–11 report the results for 14 of the 18 SNPs in Table 3 that were genotyped in 470 oldest old and 538 younger controls of the JCS. Only 3 SNPs reach statistical significance in this set (rows 1, 5 and 10) but one of them have opposite effects compared to the NECS and SICS (row 1). We did not attempt to merge the results from different populations because of the substantial differences in allele frequencies.