Microbial Ecological Instability and Non-Linear Host Interactions Shape Airway Inflammation in HIV-Associated COPD
收藏DataCite Commons2026-03-20 更新2026-05-04 收录
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https://data.mendeley.com/datasets/ny3h5kcxvg/1
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资源简介：
Chronic Obstructive Pulmonary Disease (COPD) is increasingly prevalent among people infected with human immunodeficiency virus (HIV) in sub-Saharan Africa. Yet, the ecological and immunological mechanisms linking airway microbes to mucosal inflammation remain unclear. We performed multi-omics profiling in adults from rural Uganda stratified by HIV/COPD status, integrating sputum microbiome sequencing, outer membrane vesicle (OMV) quantification, cytokine profiling, CyTOF immunophenotyping, and bulk and single-cell transcriptomics with bronchoalveolar lavage (BAL)-guided deconvolution.
提供机构：
Mendeley Data
创建时间：
2026-03-20
