Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors

Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors Descriptor: 6-ethyl-5-iodo-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one, MAGNESIUM ION, ZINC ION, ... Authors: Chen, T.T, Ren, J, Xu, Y.C. Deposit date: 2014-01-14 Release date: 2015-04-01 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.44 Å) Cite: Thermodynamic and structural characterization of halogen bonding in protein-ligand interactions: a case study of PDE5 and its inhibitors. J.Med.Chem., 57, 2014与新型抑制剂结合的磷酸二酯酶5A1（PDE5A1）催化域晶体结构 描述符：6-乙基-5-碘-2-{5-[(4-甲基哌嗪-1-基)磺酰基]-2-丙氧基苯基}嘧啶-4(3H)-酮、镁离子、锌离子…… 作者：陈婷婷（Chen, T.T.）、任杰（Ren, J.）、徐玉成（Xu, Y.C.） 提交日期：2014-01-14 发布日期：2015-04-01 最后修改日期：2024-02-28 实验方法：X射线衍射（分辨率2.44 Å） 引用文献：《蛋白质-配体相互作用中卤键的热力学与结构表征：以PDE5及其抑制剂为例》，J.Med.Chem., 57, 2014