Pleiotropic function and potential antifungal target of phosphomannose isomerase in Fusarium oxysporum f. sp. cubense

Fusarium is one of the notorious fungal pathogen causing severe wilt syndrome in many crop plants and causing mycotoxicoses in humans. Formae speciale tropical race 4 (Foc TR4) of Fusarium oxysporum f. sp. cubense damages almost all cultivars of banana plants, devastates banana production and accounts for severe economic losses throughout the world. PMI interconverts fructose-6-phosphate (Fru6P) and mannose-6-phosphate (Man6P) and links the cell wall biosynthesis to energy production. Our aim was to reveal the metabolic pathways by PMI deletion by transcriptome analysis.