Expression Profiling of developing eyes and brains in mouse embryos using NIG-NIA 15K mouse cDNA arrays. Mus musculus

The mechanisms of eye formation in the embryo vary according to developmental stage and adjacent tissues, especially the developing brain. These morphogenetic waves involve temporally interactions of transcription factors and spatially inductive signaling cascades. To throw light on the global genetic networks in regulating embryonic eye formation we used microarray hybridizations to profile the molecular changes occurring in the developing mouse eye between the stage of optic vesicle evagination at gestational day 9.5 (E9.5) and completion of basic eye formation at postnatal day 0 (P0). To display the differential molecular pattern of eye development in comparison to that of the developing brain.